Cov leeg nqaij fibers feem ntau tsim los ntawm kev sib xyaw ntawm cov neeg ua ntej myoblasts rau hauv cov fibers ntau hu ua myotubes. … Thaum qhov kev loj hlob zoo tag lawm, myoblasts tso tseg kev faib tawm thiab tau txais qhov sib txawv ntawm qhov chaw mus rau hauv myotubes Myoblast sib txawv ua rau theem.
Pob myoblasts poob lawv lub peev xwm mus rau mitosis tom qab lawv fuse rau hauv cov leeg nqaij?
Myoblasts proliferate ntau, tab sis ib zaug lawv tau fused, lawv tsis tuaj yeem faib. Fusion feem ntau ua raws li qhov pib ntawm kev sib txawv ntawm myoblast, uas ntau cov noob encoding cov nqaij leeg tshwj xeeb yog hloov ntawm kev sib koom ua ke.
Pob myoblasts undergo fusion?
Txhua myofiber yog cov khoom lag luam ntawm fusion ntawm ntau pua lossis ntau txhiab lub hlwb mononucleated leeg hu ua myoblasts. Myoblast fusion yog tseem ceebtsis yog rau cov leeg pob txha loj hlob thaum lub sij hawm embryogenesis, tab sis kuj rau satellite cell-mediated nqaij regeneration rau cov neeg laus [1, 2].
Vim li cas myoblasts fuse?
Nyob rau hauv muaj qhov pom ntawm fibroblast kev loj hlob, myoblasts fuse rau hauv ntau cov nucleated mytotubes, uas tsim lub hauv paus ntawm cov leeg nqaij. Tsis siv cov myoblasts dedifferentiate rau hauv cov hlwb myosatellite, uas nyob hauv cov nqaij fiber ntau kom txog thaum xav tau los sib txawv rau hauv cov leeg nqaij tshiab thaum cov leeg nqaij puas lossis ntxhov siab.
Lub npe ntawm cov leeg pob txha pob txha uas tshwm sim los ntawm kev sib xyaw ntawm myoblast yog dab tsi?
1.2.
Cov leeg pob txha yog tsim los ntawm cov leeg nqaij sib txuas ua ke hu ua myofibersCov myofibers no tshwm sim los ntawm kev sib xyaw ntawm myogenic progenitors ntawm mesoderm, hu ua myoblasts. Tus naj npawb ntawm myofibers tseem nyob tas li, tab sis txhua tus myofiber fuses nrog satellite hlwb, cov pejxeem ntawm cov leeg nqaij SCs.
