Ib qho tshuaj tiv thaiv yog ib yam khoom uas txhim kho lub cev tiv thaiv kab mob cov lus teb rau qhov muaj cov tshuaj tiv thaivLawv feem ntau siv los txhim kho kev siv tshuaj tiv thaiv. Feem ntau, lawv tau txhaj nrog ib qho antigen los pab lub cev tiv thaiv kab mob tsim cov tshuaj tiv thaiv kab mob uas tawm tsam cov tshuaj tiv thaiv.
Yuav ua li cas cov adjuvants txhim kho lub cev tiv thaiv kab mob?
Muaj pov thawj qhia tias cov neeg ua haujlwm kho mob siv ib lossis ntau lub tswv yim hauv qab no txhawm rau txhawm rau tiv thaiv lub cev tiv thaiv kab mob: (1) tso tawm cov tshuaj tiv thaiv nyob rau ntawm qhov chaw txhaj tshuaj (depot effect), (2) kev tswj hwm ntawm cytokines thiab chemokines, (3) cellular recruitment at the site of txhaj, (4) nce antigen uptake …
Yuav ua li cas adjuvants txhim kho lub immunogenicity ntawm antigens?
Adjuvant yog ib qho kev npaj uas txhim kho kev tiv thaiv kab mob antigen. Adjuvant yog siv nyob rau hauv zus tau tej cov polyclonal thiab monoclonal antibodies. Lub adjuvant tso cai rau lub sijhawm ntev thiab qeeb tso tawm ntawm antigen hauv lub cev. Adjuvant tseem tiv thaiv cov tshuaj tiv thaiv los ntawm qhov tsis muaj qhov tshwj xeeb stimulation ntawm lub cev tiv thaiv kab mob.
Pob adjuvants txhawb lub cev tiv thaiv kab mob rau cov tshuaj tiv thaiv nyob?
Txawm hais tias nws tau tsim muaj tseeb tias adjuvants tuaj yeem txhim kho cov tshuaj tiv thaiv kab mob rau kev txhaj tshuaj rau tib neeg, txog niaj hnub no tsis muaj cov tshuaj tiv thaiv tau pom tias ua rau muaj qhov loj ntawm cov tshuaj antigen tshwj xeeb CD8 + T cell teb txhawb los ntawm cov tshuaj tiv thaiv kab mob muaj sia xws li YF-17D (ref.109).
Yuav ua li cas yog cov tshuaj tiv thaiv kab mob?
Ib qho tshuaj tiv thaiv yog ib qho khoom siv hauv qee cov tshuaj tiv thaiv uas pab tsim kom muaj lub cev tiv thaiv kab mob zoo dua rau cov neeg tau txais cov tshuaj tiv thaiv. Hauv lwm lo lus, adjuvants pab cov tshuaj tiv thaiv ua haujlwm zoo dua.
