DNA methylation yog qhov tseem ceeb rau silencing retroviral cov ntsiab lus, tswj cov ntaub so ntswg tshwj xeeb gene qhia, genomic imprinting, thiab X chromosome inactivationTseem ceeb, DNA methylation nyob rau hauv cov cheeb tsam genomic sib txawv yuav ua rau muaj kev cuam tshuam sib txawv. ntawm cov kev ua genes raws li hauv qab genetic sequence.
Methylation yog dab tsi thiab vim li cas nws tseem ceeb?
Lub voj voog methylation pab peb ua haujlwm ntawm lub cev thiab lub hlwb , yog li nws yuav tsis xav tsis thoob tias ntau lub zog sib txawv hauv lub cev siv cov txheej txheem no. Cov haujlwm no suav nrog kev ua haujlwm ntawm lub paj hlwb, lub plawv thiab lub cev tiv thaiv kab mob,5- 8 nrog rau kev tsim hluav taws xob, hnyav-hlau detoxification thiab hormonal tshuav nyiaj li cas.
Lub hom phiaj ntawm DNA methylation yog dab tsi?
DNA methylation tswj cov noob qhia los ntawm kev nrhiav cov proteins koom nrog hauv kev tsim txom cov noob lossis los ntawm inhibiting kev khi ntawm cov khoom hloov pauv mus rau DNA Thaum lub sij hawm kev loj hlob, tus qauv ntawm DNA methylation hauv lub genome hloov raws li qhov tshwm sim ntawm cov txheej txheem dynamic uas muaj ob qho tib si de novo DNA methylation thiab demethylation.
Yuav ua li cas yog cov tshuaj methylation?
DNA methylation, txheej txheem ntawm kev ntxiv ib pawg methyl rau DNA ua los ntawm DNA methyltransferase yog ib qho cuab yeej cuab tam (epigenetic) hloov ua rau mob qog noj ntshav, atherosclerosis, mob hlab ntsha tawg (Imprinting disorders), thiab kab mob plawv..
DNA methylation yog dab tsi thiab nws txoj haujlwm yog dab tsi?
DNA methylation yog cov txheej txheem lom neeg los ntawm cov pab pawg methyl ntxiv rau DNA moleculeMethylation tuaj yeem hloov pauv cov haujlwm ntawm DNA ntu yam tsis hloov pauv. Thaum nyob rau hauv ib qho kev txhawb nqa noob, DNA methylation feem ntau ua rau txo qis kev hloov pauv noob.
