Thaum ib qho kev hloov pauv ntawm DNA strand tsim lub sijhawm ua ntej nres codon lub RNA template yuav tsis raug txhais tag nrho, ua rau cov protein nrog qhov hnyav molecular vim tsawg amino amino kua qaub residue. Raws li qhov tshwm sim, cov protein kuj yuav zoo li tsis ua haujlwm. Nov yog ib qho piv txwv ntawm kev hloov pauv tsis tseem ceeb.
Vim li cas cov proteins tsis ua haujlwm hauv qhov xwm txheej hnyav?
Vim lub tsev thaivthiab covalent bonds ntawm tag nrho cov proteins, nrog rau cov extremophilic sawv daws yuav, yog tib yam, nyob rau hauv cov ntaub ntawv ntawm huab ib puag ncig tej yam kev mob cov tshuaj constituents thiab cov qauv covalent. ntawm polypep-tide saw teeb qhov kawg txwv.
lo lus siv los piav txog cov protein uas tau nthuav tawm thiab ua tsis tau zoo?
Nws tau kwv yees tias tag nrho 25% ntawm cov khoom seem hauv cov protein nyob hauv ntau qhov sib txawv ntawm cov genomes yog nyob rau hauv cov cheeb tsam uas tsis zoo li quav rau hauv cov qauv globular [4]. … Vim tias cov proteins no zoo li yuav nthuav tawm thiab tsis muaj qhov tshwj xeeb, kuv hais rau lawv ' junk proteins'.
Yuav ua li cas thaum cov protein folds tsis raug?
Cov protein uas quav tsis raug kuj tseem tuaj yeem cuam tshuam kev noj qab haus huv ntawm tes txawm tias cov protein ua haujlwm li cas. Thaum cov proteins tsis quav ntsej rau hauv lawv lub luag haujlwm, qhov tshwm sim misfolded proteins tuaj yeem hloov mus rau hauv cov duab uas tsis zoo rau cov neeg coob coob ntawm cov cellular ib puag ncig
Yuav ua li cas yog lub tsev thaiv cov proteins?
Lub tsev blocks ntawm cov proteins yog amino acids, uas yog cov organic molecules me me uas muaj cov alpha (central) carbon atom txuas rau cov amino pawg, pawg carboxyl, a hydrogen atom, thiab cov khoom sib txawv hu ua cov saw hlau sab (saib hauv qab).
