Feem ntau cov activators ua haujlwm los ntawm binding sequence-tshwj xeeb rau lub chaw tswj hwm DNA nyob ze ntawm tus txhawb nqa thiab ua cov protein-protein cuam tshuam nrog cov tshuab luam ntawv dav dav (RNA polymerase thiab cov khoom siv dav dav.), yog li ua kom yooj yim rau kev khi ntawm cov tshuab luam ntawv dav dav rau …
Yuav ua li cas transcriptional activator proteins thiab repressors?
Cov ntsiab lus txhais yog cov proteins uas pab tig cov noob tshwj xeeb "rau" lossis "tawm" los ntawm kev khi rau DNA nyob ze. Cov kev hloov pauv uas yog activators txhawb cov noob hloov pauv. Cov neeg ntxeev siab txo qis kev sau ntawv.
Yuav ua li cas hloov cov ntsiab lus qhib tau?
Kev hloov pauv yam tseem ceeb yog qhov nyuaj thiab tuaj yeem koom nrog ntau txoj hauv kev hloov pauv hauv lub cev, suav nrog kinases PKA, MAPKs, JAKs, thiab PKCs, txhawb nqa los ntawm cell-surface receptors [8, 9]. Cov kev hloov pauv kuj tseem tuaj yeem ua ncaj qha los ntawm ligands xws li ua glucocorticoids thiab vitamins A thiab D [5].
Yuav ua li cas hloov cov ntaub ntawv txhawb nqa ua haujlwm?
Txhim kho yog kev tswj hwm deoxyribonucleic acid (DNA) ib ntus uas muab cov chaw khi rau cov proteins uas pab qhib cov ntawv sau (tsim ntawm ribonucleic acid [RNA] los ntawm DNA). Thaum cov proteins uas muaj qhov tshwj xeeb affinity rau DNA (DNA-binding protein) khi rau ib qho kev txhim kho, cov duab ntawm DNA hloov.
Yuav ua li cas activator proteins rau cov noob qhia feem ntau ua haujlwm?
Activator proteins khi rau cov chaw tswj hwm ntawm DNA nyob ze rau cov cheeb tsam txhawb nqa uas ua raws li kev hloov pauv / tawm Qhov kev khi no txhawb nqa RNA polymerase kev ua haujlwm thiab kev hloov pauv ntawm cov noob nyob ze.… Kev tswj cov noob qhia hauv eukaryotes yog qhov nyuaj dua li hauv prokaryotes.
