Anatomical terminology. Tight junctions, tseem hu ua occluding junctions los yog zonulae occludentes (singular, zonula occludens) yog multiprotein junctional complexes uas nws canonical muaj nuj nqi yog los tiv thaiv to ntawm solutes thiab dej thiab seals txoj kev paracellular.
Puas muaj kev sib tshuam nruj hauv GI ib puag ncig?
Cov kev sib tshuam nruj, lossis zonula occludens, cov ntaub ntawv ib qho kev cuam tshuam ntawm cov cell epithelial nyob rau hauv lub plab hnyuv thiab daim siabthiab, los ntawm kev txwv kev txav ntawm dej thiab solutes los ntawm qhov chaw intercellular., tuav lub physicochemical cais ntawm cov ntaub so ntswg compartments.
hom cell twg muaj kev sib tshuam nruj?
Cov kev sib tshuam nruj ntawm cov hlwb epithelial xav tias muaj ob lub luag haujlwm no. Ua ntej, lawv ua haujlwm raws li kev txwv tsis pub muaj kev sib kis ntawm qee cov membrane proteins (thiab lipids) ntawm apical thiab basolateral domains ntawm plasma membrane (saib daim duab 19-2).
Dab tsi yog qhov sib txuas sib txuas sib txuas?
Tight junctions form kev nruam intercellular barrier ntawm epithelial cells, uas yuav tsum tau cais cov ntaub so ntswg thiab tswj kev xaiv txav ntawm solutes hla lub epithelium.
piv txwv ntawm kev sib tshuam nruj yog dab tsi?
Tight epithelia muaj qhov sib txuas nruj uas tiv thaiv feem ntau ntawm cov hlwb. Piv txwv ntawm nruj epithelia muaj xws li lub distal convoluted tubule, cov ducts ntawm nephron nyob rau hauv lub raum, thiab cov kua tsib ducts ramifying los ntawm daim siab daim siab.
