Y Cyclooxygenase yuav tsum tau rau prostaglandin thiab thromboxane synthesis. Aspirin ua raws li tus neeg sawv cev acetylating qhov twg
ib pawg acetyl yog covalently txuas mus rau serine residue nyob rau hauv qhov chaw nquag ntawm COX enzyme.
Aspirin cuam tshuam rau cyclooxygenase li cas?
Aspirin ua los ntawm irreversibly acetylating ib tug serine residue ntawm txoj hauj lwm 529 nyob rau hauv platelet prostaglandin G / H synthase,4ib qho enzyme colloquially hu ua cyclooxygenase. Cov khoom tseem ceeb ntawm cyclooxygenase hauv platelets yog thromboxane A2.
Puas aspirin inhibit cyclooxygenase?
Nws tau ua pov thawj tias cov tshuaj aspirin thiab lwm cov tshuaj tsis-steroid anti-inflammatory (NSAIDs) inhibit cov haujlwm ntawm cov enzymetam sim no hu ua cyclooxygenase (COX) uas ua rau tsim cov prostaglandins. (PGs) uas ua rau mob, o, mob thiab ua npaws.
Dab tsi receptor ua tshuaj aspirin khi rau?
Cov txiaj ntsig no qhia tias cov tshuaj aspirin yog ib qho allosteric inhibitor ntawm B2 receptor, cov cuab yeej uas yuav koom nrog hauv nws cov kev kho mob.
Aspirin khi rau COX li cas?
Nws tau sau tseg zoo tias cov tshuaj aspirin irreversibly inhibits cyclooxygenase (COX) los ntawm acetylation ntawm amino acid serine residue(Daim duab 1), thiab yog li thaiv cov biosynthesis tom ntej ntawm prostaglandins thiab thromboxane..
