Definition and History. Recessive hereditary methemoglobinemia (RHM) yog ib qho autosomal recessive metabolic disorder vim NADH-cytochrome b5 reductase (cytb5r) deficiency. Cov noob uas encodes cov enzyme no nyob ntawm chromosome caj npab 22q13-qter.
methemoglobin tuaj qhov twg?
Methemoglobinemia (congenital lossis kis tau) tshwm sim thaum cov qe ntshav liab (RBCs) muaj methemoglobin ntawm qib siab dua 1%. Methemoglobin tshwm sim los ntawm muaj hlau nyob rau hauv daim ntawv ferric es tsis txhob ntawm ib txwm ferrous daim ntawv. Qhov no ua rau txo qis cov pa oxygen rau cov ntaub so ntswg.
Thaum twg methemoglobin tsim?
Methemoglobin cov ntaub ntawv thaum hemoglobin yog oxidized kom muaj hlau hauv ferric[Fe3+] es tsis yog lub xeev ferrous [Fe2+]. Ib qho ntawm plaub hom hlau nyob hauv ib lub hemoglobin molecule uas nyob hauv daim ntawv ferric tsis tuaj yeem khi oxygen.
methemoglobin yog dab tsi yog nws qhov tseem ceeb?
pigment nyob rau hauv uas lub heme-hlau yog nyob rau hauv trivalent daim ntawv (ferric-hlau). Qhov no. Yog li ntawd, pigment tseem hu ua hemiglobin lossis hemoglobin III. Yog li. methemoglobin yog an oxidized hemoglobin, oxy-hemoglobin ntawm.
YPeb puas muaj methemoglobin?
Ib txwm, hemoglobin tom qab ntawd tso cov pa oxygen rau cov hlwb thoob plaws hauv koj lub cev. Txawm li cas los xij, muaj ib hom hemoglobin hu ua methemoglobin uas nqa oxygen los ntawm koj cov ntshav tab sis tsis tso tawm mus rau cov hlwb.
