Methylation yog qhov sib ntxiv ntawm pawg methyl mus rau lysine sab saw lub luag haujlwm rau chromatin transcription ua haujlwm xeev. Sulfation yog ib qho kev hloov pauv mus tas li xav tau rau kev ua haujlwm ntawm cov protein. … Kev ua kom huv ntawm cov protein hloov tom qab hloov pauv yog xav tau.
Puas yog DNA methylation post transcriptional hloov kho?
Methylation ntawm DNA thiab kev hloov kho ntawm histones tswj kev hloov pauv, thiab cov txheej txheem xws li ubiquitinization, autophagy thiab microRNAs tswj kev txhim kho post-transcriptionally. Txhua yam ntawm cov kev cai no muaj zog heev nyob rau hauv lub embryo thaum ntxov.
hom kev hloov pauv dab tsi yog DNA methylation?
Nyob hauv tshooj no, peb yuav qhia txog qhov tseem ceeb ntawm cov txheej txheem epigenetic uas cuam tshuam nrog ncaj qha tshuaj hloov khorau DNA hu ua DNA methylation. Keeb kwm, DNA methylation tau pom nyob rau hauv cov tsiaj nyeg thaum ntxov raws li DNA tau txheeb pom tias yog cov khoom siv caj ces (Avery li al, 1944; McCarty thiab Avery, 1946).
4 hom kev hloov pauv tom qab kev txhais lus yog dab tsi?
Cov kev hloov kho no suav nrog phosphorylation, glycosylation, ubiquitination, nitrosylation, methylation, acetylation, lipidation thiab proteolysisthiab cuam tshuam yuav luag txhua yam ntawm cov cell biology thiab pathogenesis.
Puas yog histone methylation hloov tom qab kev txhais lus?
Kev hloov pauv histone yog a covalent tom qab kev hloov pauv hloov pauv(PTM) rau cov proteins histone uas suav nrog methylation, phosphorylation, acetylation, ubiquitylation, thiab sumoylation. Cov PTMs ua rau histones tuaj yeem cuam tshuam cov noob qhia los ntawm kev hloov cov qauv chromatin lossis nrhiav cov hloov kho histone.
