Kev kho mob nrog ib tus neeg sawv cev abiraterone ua rau muaj qhov tsis txaus ntawm glucocorticoid synthesis thiab yog li ua rau kev them nyiaj rov qab ntawm hypothalamic-pituitary-adrenal (HPA) nrog nce qib ntawm adrenocorticotrophic hormone (ACTH) [5]. Qhov no feem ntau ua rau muaj qhov nce ntawm cov mineralocorticoid ntau lawm.
Puas abiraterone ua rau hypokalemia?
Hauv xyoo 2011, abiraterone acetate tau pom zoo rau kev kho mob ntawm metastatic CRPC; Txawm li cas los xij, abiraterone paub tias ua rau cov kab mob mineralocorticoid ntau dhau los ntawm hypokalemia, kua dej, thiab kub siab. Peb tau ntsib ob qhov xwm txheej ntawm qib 4 hypokalemia cuam tshuam nrog kev kho abiraterone.
Abiraterone ua rau mob ntshav siab li cas?
Raws li cov chaw tsim khoom pob ntxig hais txog cov lus ceeb toom thiab kev ceev faj, kev kub siab nrog rau hypokalemia thiab cov kua dej khaws cia tuaj yeem tshwm sim los ntawm abiraterone li qhov tshwm sim ntawm nce qib mineralocorticoid uas ua los ntawm CYP17 inhibition.
Vim li cas koj thiaj muab tshuaj steroids nrog abiraterone?
Kev tswj hwm ntawm abiraterone acetate nrog glucocorticoids yog tsim nyog los tswj cov xwm txheej tsis zoo cuam tshuam nrog cov mineralocorticoid ntau dhau, xws li hypokalemia, kub siab, thiab dej tuav, uas tuaj yeem tshwm sim los ntawm CYP17A1 inhibition [6–8].
Lub luag haujlwm ntawm prednisone thaum ua ke nrog abiraterone yog dab tsi?
Abiraterone yog siv ua ke nrog cov tshuaj steroid prednisone txhawm rau txo qis kev pheej hmoo ntawm kev kub siab, Fizazi hais. Fizazi hais tias "Qhov peb tau kawm txog abiraterone yog qhov ua tau zoo dua li docetaxel," Fizazi hais.
