PCNA (proliferating cell nuclear antigen) tau pom nyob rau hauv cov nuclei ntawm cov poov xab, cov nroj tsuag thiab cov tsiaj hlwb uas dhau los ntawm cell division, qhia txog kev ua haujlwm hauv cell voj voog tswj thiab / lossis DNA replication. Tom qab ntawd nws tau pom meej tias PCNA kuj tau ua lub luag haujlwm hauv lwm cov txheej txheem cuam tshuam nrog cov genome ntawm tes.
PCNA kev ua haujlwm yog dab tsi?
Proliferating cell nuclear antigen (PCNA) plays lub luag haujlwm tseem ceeb hauv nucleic acid metabolism ua ib feem ntawm kev rov ua dua thiab kho tshuab. Qhov no toroidal-zoo li tus protein encircles DNA thiab muaj peev xwm swb ob-directionally raws duplex.
PCNA thawj zaug pom qhov twg?
Miyachi et al. (1978) thawj zaug txheeb xyuas qhov auto-antigen hauv cov neeg mob uas muaj kab mob lupus erythematosis, uas lawv hu ua PCNA vim tias cov protein tau pom nyob rau hauv lub nucleus ntawm kev faib hlwb.
PCNA loj npaum li cas?
Proliferating cell nuclear antigen (PCNA), ib qho protein ntawm 30 kDa qhov hnyav molecular kuj hu ua cyclin, tsim lub nplhaib trimer nyob ib ncig ntawm DNA ob-helix. Nws khi rau ntau yam ntawm lwm cov proteins nuclear thiab yog li npaj cov txheej txheem biochemical ntawm DNA replication diav rawg.
Lub luag haujlwm ntawm PCNA yog dab tsi hauv eukaryotic replication?
Proliferating cell nuclear antigen (PCNA) plays lub luag haujlwm tseem ceeb hauv ntau yam ntawm DNA replication thiab replication-associated txheej txheem, suav nrog translesion synthesis, yuam kev tsis muaj kev puas tsuaj bypass, tawg-induced replication, kho tsis sib haum, thiab chromatin sib dhos.
