Ntxiv rau cov poov xab thiab cov qog ntshav, nco B hlwb muaj nyob hauv pob txha pob txha, Peyers ' thaj ua rau thaj, gingiva, mucosal epithelium ntawm tonsils, lamina propria ntawm lub plab hnyuv, thiab nyob rau hauv txoj kev (67, 71–76).
nco B hlwb tuaj qhov twg?
Cov hlwb tshwm sim los ntawm T-cell nyob ntawm cov tshuaj tiv thaiv hauv lub chaw kab mobthiab yog hom cell tseem ceeb rau kev tiv thaiv kab mob kom rov sib tw los ntawm antigen. Txawm hais tias, zoo li plasma hlwb, nco B hlwb sib txawv ntawm GC cov tshuaj tiv thaiv, lawv tsis tso cov tshuaj tiv thaiv kab mob thiab tuaj yeem ua rau nws tus kheej ntawm antigen [85].
nco lymphocytes nyob qhov twg?
Central nco T hlwb tshwm sim hauv cov qog ntshav hauv nruab nrab, feem ntau hauv cov qog thiab cov tonsils, nrog cov molecules hauv qab no ntawm lawv qhov chaw: CD45RO, CCR7, CD62L, CD44, CD27, CD28, CD95, CD122 [5, 7, 8] thiab LFA-1 (CD11a/CD18) molecules interacting with APCs [9].
Lub hlwb puas tsim tau?
Nco B hlwb yog B cell sub-hom uas tau tsim ua raws tus kab mob thawj zaugTom qab thawj zaug (thawj teb) tus kab mob cuam tshuam nrog qee yam antigen, cov lus teb. naïve hlwb (cov uas tsis tau raug cov antigen) proliferate los tsim ib tug colony ntawm hlwb.
Thaum twg lub cim xeeb B hlwb tsim?
Nco B hlwb raug tsim los teb rau T-dependent antigens, thaum lub sij hawm GC cov tshuaj tiv thaiv, nyob rau hauv parallel mus rau plasma hlwb (Fig. 2-5). Thaum lawv tawm ntawm GCs, nco B hlwb tau txais cov khoom tsiv teb tsaws mus rau thaj chaw extrafollicular ntawm tus po thiab cov nodes.
