Striatal cholinergic interneurons (CINs) yog qhov tseem ceeb ntawm acetylcholine hauv striatum thiab ntseeg tias ua lub luag haujlwm tseem ceeb hauv basal ganglia physiology thiab pathophysiology. … Piv txwv li, tam sim no nws muaj peev xwm tshawb xyuas qhov luv luv inhibition ntawm CIN kev ua ub ua no zoo li striatal zog.
cholinergic interneurons ua dab tsi?
Cholinergic interneurons (CINs) yog tseem ceeb regulators ntawm striatal network kev ua ub no thiab tso zis … Qhov nce ntawm CIN firing los ntawm CRF ua rau kom muscarinic acetylcholine receptors hom 5, uas kho potentiation. ntawm dopamine kis nyob rau hauv lub striatum.
hom neurons twg nyob hauv striatum?
Lawv lub ntsiab lus tswv yim, striatum, yog lub hauv paus rau txoj haujlwm no. Nws muaj ob hom kev kwv yees neurons, ua ke sawv cev 95% ntawm cov neurons, thiab 5% ntawm interneurons, ntawm cov uas yog cov cholinergic, ceev-spiking, thiab qis-spiking subtypes.
cholinergic interneurons nyob qhov twg?
Intrinsic cholinergic neurons muaj nyob hauv lub paj hlwb cortex, striatum, hippocampus, nucleus accumbens, thiab lwm qhov chaw uas lawv muaj feem ntau yog interneurons lossis nyob sib ze nrog cov ntaub so ntswg uas tsis yog neuronal. Cholinergic interneurons feem ntau cuam tshuam nrog dopaminergic system, zoo li cov ntaub ntawv hauv striatum.
Dab tsi yog Tonically nquag nquag neuron?
Taw qhia. Tonically nquag nquag neurons (TANs) tsim ib pawg ntawm cov neurons hauv striatum uas tau nkag siab los ntawm lawv cov yam ntxwv spiking hauv cov kev tshawb fawb electrophysiological ua rau tsiaj coj tus cwj pwm (Apicella, 2002).
