Cov txheej txheem:
- Dab tsi yog lub teeb liab rau kev degradation protein?
- Yuav ua li cas tshem tawm cov protein degradation ntawm cov protein tshwm sim?
- proteasomal degradation tshwm sim nyob qhov twg?
- Lub hom phiaj ntawm cov protein rau degradation yog dab tsi?
Video: Dab tsi ntawm cov hauv qab no yog lub teeb liab rau proteasomal degradation?
2024 Tus sau: Fiona Howard | [email protected]. Kawg hloov kho: 2024-01-10 06:38
Polyubiquitination tau ntev tau paub tias yog "canonical" teeb liab tsom cov proteins rau degradation los ntawm proteasome.
Dab tsi yog lub teeb liab rau kev degradation protein?
Ib lub teeb liab degradation los yog 'degron' 10, feem ntau txhais tau tias yog ib qho me me hauv cov protein uas txaus rau kev lees paub thiab degradation los ntawm cov khoom siv proteolytic. Ib qho khoom tseem ceeb ntawm degron yog tias lawv hloov tau.
Yuav ua li cas tshem tawm cov protein degradation ntawm cov protein tshwm sim?
Proteins raug cim rau kev degradation los ntawm qhov txuas ntawm ubiquitin rau cov amino pawg ntawm cov saw ntawm cov lysine residueTom qab ntawd ntxiv ubiquitins ntxiv los ua ib txoj hlua multiubiquitin. Xws li cov protein ntau polyubiquinated tau lees paub thiab degraded los ntawm qhov loj, multisubunit protease complex, hu ua proteasome.
proteasomal degradation tshwm sim nyob qhov twg?
Ntau cov protein ntau yog degraded los ntawm 26S Proteasome
Cov qauv no muaj nyob hauv cov nucleus thiab cov cytosol ntawm tag nrho cov hlwbthiab suav txog kwv yees li 1 txog 2% ntawm cell mass (39).
Lub hom phiaj ntawm cov protein rau degradation yog dab tsi?
Hauv cov hlwb eukaryotic, ATP-dependent protease hu ua proteasome yog lub luag haujlwm rau ntau ntawm cov proteolysis no. Proteins yog tsom rau proteasomal degradation los ntawm a ob-ntu degron, uas muaj cov teeb liab sib txuas proteasome thiab qhov chaw pib degradation.
Pom zoo:
Nyob rau hauv pob liab liab liab liab yog?
Cov cim qhia thiab cov tsos mob uas ua rau liab liab ua npaws nws lub npe suav nrog: liab pob liab. Cov pob khaus zoo li lub hnub ci thiab zoo li cov ntawv xuab zeb. Nws feem ntau pib ntawm lub ntsej muag lossis caj dab thiab kis mus rau lub cev, caj npab thiab txhais ceg .
Dab tsi yog lub cev lub cev uas ua haujlwm ntawm lub teeb liab?
A system tuaj yeem txhais tau tias yog lub cev khoom siv ua haujlwm ntawm lub teeb liab. Piv txwv li, ib qho amplifier yog siv los ua kom nrov nrov input signal amplitude. Nyob rau hauv cov ntaub ntawv no, lub amplifier ua ib co kev khiav hauj lwm (s) ntawm lub teeb liab, uas muaj cov nyhuv ntawm nce lub amplitude ntawm qhov xav tau cov ntaub ntawv-cov kabmob teeb liab .
Puas yog lub teeb liab lossis lub teeb liab?
As adjective qhov txawv ntawm chappy thiab choppy yog tias chappy yog tag nrho ntawm chaps; cleft; qhov khoob; qhib thaum choppy yog (ntawm cov dej saum npoo av) muaj ntau me me, ntxhib nthwv dej . Chappy txhais li cas? [chiefly British]
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Dab tsi ntawm cov hauv qab no txo qis los ntawm laminating lub hauv paus ntawm lub tshuab hloov pauv? Hysteresis poob . Lub hom phiaj ntawm laminating cov tub ntxhais hauv lub transformer yog dab tsi? Cov tub ntxhais hlau ntawm lub tshuab hloov pauv yog laminated nrog cov ntawv nyias;
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