Polyubiquitination tau ntev tau paub tias yog "canonical" teeb liab tsom cov proteins rau degradation los ntawm proteasome.
Dab tsi yog lub teeb liab rau kev degradation protein?
Ib lub teeb liab degradation los yog 'degron' 10, feem ntau txhais tau tias yog ib qho me me hauv cov protein uas txaus rau kev lees paub thiab degradation los ntawm cov khoom siv proteolytic. Ib qho khoom tseem ceeb ntawm degron yog tias lawv hloov tau.
Yuav ua li cas tshem tawm cov protein degradation ntawm cov protein tshwm sim?
Proteins raug cim rau kev degradation los ntawm qhov txuas ntawm ubiquitin rau cov amino pawg ntawm cov saw ntawm cov lysine residueTom qab ntawd ntxiv ubiquitins ntxiv los ua ib txoj hlua multiubiquitin. Xws li cov protein ntau polyubiquinated tau lees paub thiab degraded los ntawm qhov loj, multisubunit protease complex, hu ua proteasome.
proteasomal degradation tshwm sim nyob qhov twg?
Ntau cov protein ntau yog degraded los ntawm 26S Proteasome
Cov qauv no muaj nyob hauv cov nucleus thiab cov cytosol ntawm tag nrho cov hlwbthiab suav txog kwv yees li 1 txog 2% ntawm cell mass (39).
Lub hom phiaj ntawm cov protein rau degradation yog dab tsi?
Hauv cov hlwb eukaryotic, ATP-dependent protease hu ua proteasome yog lub luag haujlwm rau ntau ntawm cov proteolysis no. Proteins yog tsom rau proteasomal degradation los ntawm a ob-ntu degron, uas muaj cov teeb liab sib txuas proteasome thiab qhov chaw pib degradation.
