Txhua cov amino acids muaj nyob hauv α-helices, tab sis glycine thiab proline tsis tshua muaj, vim lawv ua rau α-helix destabilizes. Glycine raug zam los ntawm ntau yam kev txwv tsis pub vim nws tsis muaj β carbon. … Proline, ntawm qhov tod tes, yog nruj heev.
Yuav ua li cas cov amino acid tsis pom nyob rau hauv alpha helices?
Proline tsis pom nyob rau hauv alpha helical qauv ntawm cov proteins, vim nws muaj cov qauv tshwj xeeb cyclic (nws yog ib qho imino acid tsis yog amino acid) m hom qauv thib ob muaj tshwj xeeb dav thiab tus naj npawb ntawm cov amino acids residues / tig. Yog li ntawd proline yog txiav txim siab raws li alpha helical breaker.
Vim li cas glycine yog alpha helix breaker?
Proline thiab glycine qee zaum hu ua "helix breakers" vim lawv cuam tshuam qhov tsis tu ncua ntawm α helical qaum conformation; Txawm li cas los xij, ob qho tib si muaj peev xwm sib txawv txawv thiab feem ntau pom nyob rau hauv lem.
glycine nyob rau hauv alpha helix nyob qhov twg?
Muaj peb txoj haujlwm hauv helix-tig-helix motif uas tau txais kev txuag zoo heev. Ib qho alanine feem ntau pom ntawm txoj hauj lwm 5 hauv thawj α helix; ib glycine pom ntawm txoj hauj lwm 9, thawj txoj hauj lwm ntawm tig; thiab valine lossis isoleucine feem ntau pom nyob rau ntawm txoj haujlwm 15 hauv qhov thib ob α helix.
Puas glycine residues feem ntau pom nyob rau hauv alpha helices?
Glycine, nrog nws ntau qhov ua tau zoo ntawm cov saw hlau, yog kuj tsis tshua pom muaj nyob hauv helices. Paub tias yuav ua li cas cov amino acid yuav tshwm sim hauv alpha helix (lub npe hu ua helix propensities), nws muaj peev xwm kwv yees qhov twg helices tshwm sim hauv cov protein ntau.
