Cov txheej txheem:
- Vim li cas ho tsis sib tw inhibitors tsis cuam tshuam Km?
- Puas kev sib tw inhibitors cuam tshuam Km?
- Yuav ua li cas irreversible inhibitors cuam tshuam Km thiab Vmax?
- Yuav ua li cas rau Vmax thiab Km hauv kev txwv tsis pub muaj kev sib tw?
Video: Puas txwv tsis pub muaj kev sib tw cuam tshuam rau km?
2024 Tus sau: Fiona Howard | [email protected]. Kawg hloov kho: 2024-01-10 06:38
Uncompetitive inhibitors Uncompetitive inhibitors Uncompetitive inhibitors yuav txo ob leeg vmax thiab pom meej Km los ntawm tib yam [v max, i=vmax/(1 + C i/Ki), and Km, app=Km/(1 + Ci/ /Ki) Qhov txo qis hauv Km tshwm sim los ntawm cov tshuaj tiv thaiv ES + I ⇔ ESI, uas txo cov tus nqi ntawm ES thiab ua rau E + S ⇔ ES equilibrium hloov mus rau sab xis. https://www.sciencedirect.com › uncompetitive-inhibitor
Uncompetitive Inhibitor - tus txheej txheem cej luam | ScienceDirect Topics
khi tsuas yog rau cov enzyme-substrate complex, tsis yog rau cov enzyme dawb, thiab lawv txo kcat thiab Km(qhov txo qis hauv Km stems los ntawm qhov tseeb tias lawv muaj rub tawm. Lub kaw lus deb ntawm cov enzyme dawb mus rau enzyme-substrate complex).
Vim li cas ho tsis sib tw inhibitors tsis cuam tshuam Km?
Thaum tus tsis sib tw inhibitor ntxiv Vmax hloov, thaum Km tseem tsis hloov. … Hauv kev txwv tsis pub muaj kev sib tw, tus inhibitor khi rau ib qho chaw allosteric thiab tiv thaiv cov enzyme-substrate complex los ntawm kev ua cov tshuaj tiv thaivQhov no tsis cuam tshuam rau Km (affinity) ntawm cov enzyme (rau lub substrate).
Puas kev sib tw inhibitors cuam tshuam Km?
Kev sib tw inhibitors tuaj yeem khi rau E thiab tsis yog ES. Lawv nce Km los ntawm kev cuam tshuamnrog kev khi ntawm cov substrate, tab sis lawv tsis cuam tshuam Vmax vim tias tus inhibitor tsis hloov cov catalysis hauv ES vim nws tsis tuaj yeem khi rau ES.
Yuav ua li cas irreversible inhibitors cuam tshuam Km thiab Vmax?
Yog tias qhov concentration ntawm irreversible inhibitor tsawg dua qhov concentration ntawm enzyme, tus inhibitor irreversible yuav tsis cuam tshuam Km thiab yuav txo Vmax. Yog hais tias qhov concentration ntawm irreversible inhibitor yog ntau tshaj qhov concentration ntawm enzyme, tsis muaj catalysis yuav tshwm sim.
Yuav ua li cas rau Vmax thiab Km hauv kev txwv tsis pub muaj kev sib tw?
Ib yam thib peb ntawm enzymatic inhibition yog qhov tsis sib tw inhibition, uas muaj cov khoom khib nyiab ntawm qhov txo qis Vmax thiab txo Km. … Yog li, paradoxically, uncompetitive inhibition ob qho tib si txo Vmax thiab nce ib enzyme affinity rau nws substrate.
Pom zoo:
Cuam tshuam lossis cuam tshuam li cas cuam tshuam kev sib txuas lus?
Txhua zaus peb tham lossis mloog, muaj tej yam uas nkag mus rau hauv txoj kev sib txuas lus meej-yam uas cuam tshuam rau tus neeg txais tau cov lus los ntawm tus xa. Qhov kev cuam tshuam no yog hu ua " noise," thiab muaj ntau hom suab nrov uas tuaj yeem ua rau cov lus raug txhais tsis raug .
Qhov kev sib npaug twg sawv cev rau kev sib raug zoo uas tsis muaj feem cuam tshuam?
Linear equations tuaj yeem sau rau hauv daim ntawv y=mx + b. Thaum b ≠ 0, kev sib raug zoo ntawm x thiab y yog qhov tsis sib xws. x + 10 muab y, txoj kab uas hla ntawm tsob ntoo hauv ntiv tes, tom qab x xyoo . Qhov kev sib npaug twg sawv cev rau kev sib raug zoo tsis sib xws?
Puas yog qhov kev thov tsis raug cuam tshuam cuam tshuam rau tus nqi pov hwm?
Feem ntau, tsis muaj qhov yuam kev yuav tsis ua rau koj cov nqi fajseeb khomob nceQhov no yog vim tus neeg ua txhaum cai tus kws kho mob yuav lav koj cov nqi kho mob thiab kho tsheb. Yog tias koj tus neeg tuav pov hwm tsis tas yuav rho nyiaj tawm, koj cov nqi them yuav tsis nce .
Nyob rau hauv ib qho kev tsis sib haum xeeb pn kev sib tshuam cov kev sib tshuam tam sim no ntawm qhov sib npaug yog?
Nyob rau hauv qhov tsis ncaj ncees PN-kho qhov kev sib tshuam tam sim no ntawm qhov sib npaug yog zero, vim tias sib npaug tab sis cov neeg nqa khoom hla hla kev sib tshuam . Thaum pn kev sib tshuam tsis ncaj ncees qhov kev sib tshuam tam sim no ntawm qhov sib npaug yog?
Qhov twg hauv qab no yog piv txwv ntawm kev cuam tshuam kev cuam tshuam?
Piv txwv ntawm kev cuam tshuam muaj xws li roob, hav zoov, suab puam, nroog thiab lub cev dej. Qee qhov kev thaiv no thaiv kev tsiv teb tsaws ntawm qee hom, thaum lawv tsis ua kom qeeb lwm hom tsiaj . piv txwv ntawm kev cuam tshuam kev cuam tshuam yog dab tsi?
