Qhov tseem ceeb, kev qaug dab peg ntawm meropenem tsis tshua muaj (0.1%), txawm tias cov neeg mob lub raum tsis zoo. Hauv cov ntsiab lus, meropenem muaj qhov kev nyab xeeb zoo heev thiab yog li tsim nyog siv rau cov neeg laus thiab / lossis cov neeg mob lub raum tsis zoo.
YPuas yog meropenem nephrotoxic?
Keeb Kwm: Carbapenems yog ib chav kawm tshiab ntawm cov tshuaj tua kab mob beta-lactam uas muaj cov kab mob dav dav ntawm cov tshuaj tua kab mob. Meropenem (MER), ib qho carbapenem tshiab tau qhia qis dua nephrotoxic peev xwmpiv rau imipenem (IMI).
Puas meropenem puas xav tau kev kho lub raum?
Lub raum tsis ua haujlwm / lim ntshav: yuav tsum tau hloov kho - 750 mg txhua 12 teev rau creatinine tshem tawm ntawm 20–40 ml / min; 500 mg txhua 12 teev rau creatinine tshem tawm <20 ml / min. Txoj kev tswj hwm IV nkaus xwb; Tsis nqus qhov ncauj.
Peb puas tuaj yeem muab meropenem thaum lub sijhawm lim ntshav?
Nws qhov siab tshaj plaws plasma concentrations tom qab txhaj tshuaj ntawm 0.5 lossis 1 g yog 25 thiab 50 mg / L, feem. Nws yog tshem tawm tsuas yog los ntawm lub raum excretion thiab nws tshem tawm ib nrab-lub neej yog 1 h. Meropenem tau zoo tshem tawm los ntawm haemodialysis, nrog rau kev lim ntshav ntawm 80 mL / min.
Cov tshuaj tua kab mob twg muaj kev nyab xeeb hauv lub raum tsis ua haujlwm?
- Gentamicin.
- YCefazolin.
- YFluoroquinolone.
- Levofloxacin
- YCiprofloxacin.
