T cell anergy yog dab tsi?

Cov txheej txheem:

T cell anergy yog dab tsi?
T cell anergy yog dab tsi?

Video: T cell anergy yog dab tsi?

Video: T cell anergy yog dab tsi?
Video: Tshuaj theem vim li cas thiaj tau nqi ?/ Siv kho mob dab tsi?/paris polyphylla use for? 2024, Hlis ntuj nqeg
Anonim

T cell anergy yog ib qho kev kam rau siab uas cov lymphocyte yog intrinsically functionally inactivated tom qab ib tug antigen ntsib, tab sis tseem ciaj sia nyob rau lub sij hawm ntev ntawm lub xeev hyporesponsive.

Dab tsi ua rau T anergy?

Kev npau taws hauv T hlwb tuaj yeem raug ntxias los ntawm Ionomycin , ionophore muaj peev xwm nce intracellular concentration ntawm calcium ions artificially. Conversely, Ca+II chelators xws li EGTA tuaj yeem ua rau Calcium ions ua rau lawv tsis tuaj yeem ua rau npau taws.

T-cell anergy tshwm sim nyob qhov twg?

Ib qho kev tswj hwm tsis zoo yog clonal anergy, uas yog lub xeev hyporesponsive uas tshwm sim thaum T cells tau qhib los ntawm T-cell antigen receptor nyob rau hauv qhov tsis muaj qhov tsim nyog co-stimulatory signals.

Dab tsi yog qhov cim uas ua rau muaj kev ntxhov siab ntawm T hlwb?

Cov kev tshawb fawb nas thawj zaug tau hais tias B7-H1 / PD-1 signaling txoj hauv kev sib kho CD8+ T cell ua haujlwm qaug zog hauv cov ntsiab lus ntawm kev kis kab mob ntev, thiab PD-1 tau npaj los ua tus cim rau T cells [29].

Koj txhais li cas los ntawm npau taws?

Ntshai: Ib lub xeev ntawm kev tiv thaiv tsis tau teb. Induced thaum T cell's antigen receptor yog stimulated, zoo khov T cell teb tseem tos "thib ob lub teeb liab" los ntawm cov antigen-presenting cell.

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