Conjugated bile acids yog dej-soluble, amphipathic, membrane-impermeable kawg cov khoom ntawm cov roj cholesterol metabolismCov haujlwm tseem ceeb ntawm cov kua tsib acids hauv daim siab, biliary ib ntsuj av, thiab cov hnyuv me muaj tam sim no tau qhia meej, tab sis cov haujlwm tshiab yuav raug tshawb pom yav tom ntej.
Vim li cas peb thiaj sib txuas cov kua tsib?
Kev sib txuas nrog glycine lossis taurine txo pKa ntawm cov kua tsib acids, txhim kho cov dej solubility, thiab txo lipophilicity[40]. Cov ntaub ntawv dhau los hais tias pKa qhov tseem ceeb ntawm cov kua tsib tsis sib txuas yog 5–6, thaum cov glycine thiab taurine conjugated bile acids yog 4–5 thiab 1–2, raws li [18].
cov kua tsib nyob qhov twg?
Conjugated bile acids yog secreted hla lub hepatocyte canalicular lumen, hla mus rau intrahepatic bile ducts, ces muab cia rau hauv lub gallbladder, tos hormonal signals kom khoob tom qab noj mov.
Yuav ua li cas yog bile acids?
Bile acids yog saturated, hydroxylated C24 cyclopentanephenanthrene sterolsCov kua tsib tseem ceeb, xws li cholic thiab chenodeoxycholic acids, yog tsim los ntawm cov roj cholesterol hauv daim siab, sib txuas rau taurine lossis glycine, thiab tom qab ntawd tso tawm los ntawm canaliculi mus rau hauv lub biliary system.
Puas kua tsib ntsev ua ke?
Cov kua ntsev yog ua los ntawm cov kua tsib uas yog conjugated nrog glycine lossis taurine. Lawv tsim nyob rau hauv daim siab, ncaj qha los ntawm cov cholesterol. Cov kua tsib ntsev yog ib qho tseem ceeb hauv kev solubilizing cov rog hauv cov dej ib puag ncig ntawm cov hnyuv.
