Hyperexcitability ntawm peripheral neurons yog tej zaum qhov tseem ceeb tshaj plaws pathophysiologic nyhuv ntawm hypocalcemia, tab sis hyperexcitability tshwm sim nyob rau txhua theem ntawm lub paj hlwb, suav nrog lub cev muaj zog endplates, tus txha caj qaum reflexes, thiab cov Central paj hlwb.
Vim li cas hypercalcemia txo qis excitability?
High Ca2+ qib tuaj yeem thaiv sodium txav los ntawm qhov hluav taws xob-gated sodium channels, txo qis sodium nkag mus rau hauv daim nyias nyias. Yog li, kev tsim cov peev txheej ua tau raug hloov pauv hauv cov neurons nrog rau cov pob txha thiab cov leeg mob plawv.
Yuav ua li cas hypocalcemia cuam tshuam qhov peev xwm ua haujlwm?
Hypocalcemia: Hypocalcemia cuam tshuam feem ntau yog L-hom calcium channel, thiab ua rau lub sijhawm 2 ntawm lub plawv muaj peev xwm. Qhov no tuaj yeem pom hauv ECG raws li kev ncua ntev ntawm ST-segment. Calcium channels kaw thaum kawg ntawm theem 2.
Dab tsi yog qhov cuam tshuam ntawm hypocalcemia?
Lub sijhawm dhau mus, hypocalcemia tuaj yeem cuam tshuam rau lub hlwb thiab ua rau cov tsos mob ntawm neurologic lossis puas siab puas ntsws, xws li tsis meej pem, nco tsis tau, delirium, kev nyuaj siab, thiab hnov lus. Cov tsos mob no ploj mus yog tias qib calcium rov qab los.
Vim li cas hypocalcemia ua rau nce sodium permeability?
Ionized hypocalcemia ua kom cov membrane excitability los ntawm kev tso cai rau nws tus kheej perpetuating sodium permeability mus txog nrog ib tug tsawg dua degree ntawm depolarization, whereas ionized hypercalcemia yuav tsum tau ntau dua li ib txwm depolarization rau qhov pib no. mus txog (saib daim duab 5-2).
