Ib qho ua kom muaj zog pib hloov pauv ntawm nws RNA ua ntej ua kom cov ntaub ntawv hloov pauv ntawmtus xa xov RNA los ntawm nws lub hom phiaj gene.
Yuav ua li cas thiaj li cuam tshuam rau kev sau ntawv?
Txhim kho cov kab ke yog cov txheej txheem DNA tswj hwm uas, thaum khi los ntawm cov proteins tshwj xeeb hu ua cov khoom hloov pauv, txhim kho cov kev hloov pauv ntawm cov noob caj noob cesTsis tas li ntawd, cov kab ke txhim kho tuaj yeem muab tso rau hauv ob qho tib si rau pem hauv ntej lossis reversed kab lus orientations thiab tseem muaj feem cuam tshuam cov noob transcription. …
Pob txhim kho pib hloov pauv?
Txoj kev txhim kho yog cov txheej txheem tswj hwm uas qhib kev txhawb nqa kev hloov pauvhla qhov deb loj thiab ntawm nws tus kheej ntawm kev taw qhia (Serfling li al.1985). Txawm hais tias ob tus neeg txhawb nqa thiab cov neeg txhawb nqa tau paub txog khi cov ntsiab lus hloov pauv (TFs), tsuas yog cov neeg txhawb nqa tau xav tias yuav pib sau los ntawm RNA polymerase II (Pol II).
Yuav ua li cas hloov pauv tau?
Txhim kho yog feem ntau tau sau tseg hauv xovtooj ntawm tes thiab tej zaum yuav ua rau lub xeev ntawm tes. Cov qib Cga eRNA tau pom los cuam tshuam txog qib theem ntawm kev txhawb nqa kev ua haujlwm, raws li tsab ntawv ceeb toom tias qhov kev txhim kho no txhawb nqa cov basal thiab cov ntaub so ntswg tshwj xeeb ntawm Cga gene.
Yuav ua li cas hloov cov ntaub ntawv txhawb nqa ua haujlwm?
Txhim kho yog kev tswj hwm deoxyribonucleic acid (DNA) ib ntus uas muab cov chaw khi rau cov proteins uas pab qhib cov ntawv sau (tsim ntawm ribonucleic acid [RNA] los ntawm DNA). Thaum cov proteins uas muaj qhov tshwj xeeb affinity rau DNA (DNA-binding protein) khi rau ib qho kev txhim kho, cov duab ntawm DNA hloov.
