Yog tias muaj qhov cim nce ntawm cov cell nrog micronuclei, nws tuaj yeem xaus lus tias tshuaj induces structural thiab/los yog zauv chromosomal puas… Nws tom qab ntawd hloov mus rau hauv lub CBMN 'cytome' assay txhawm rau tshawb nrhiav kev tuag ntawm tes, cytostasis, thiab biomarkers ntawm DNA puas.
Micronucleated cells yog dab tsi?
Micronuclei yog me me DNA-muaj cov qauv tsim hluav taws xob uas raug cais tawm ntawm lub ntsiab nucleusLawv nquag pom hauv pathologies, suav nrog mob qog noj ntshav. … Txawm hais tias micronuclei yog cov qauv me me, qhov cuam tshuam lawv muaj rau cov hlwb thiab lawv cov microenvironment loj heev.
Qhov tseem ceeb ntawm micronucleus yog dab tsi?
Micronucleus (MN) yog lub cev extranuclear ntawm qhov puas tsuaj ntawm chromosome feem ntau yog siv los tshuaj xyuas cov muaj peev xwm ntawm cov tshuaj genotoxic Kev tshawb nrhiav DNA puas ntawm qib chromosome yog qhov tseem ceeb ntawm kev kuaj genotoxicity vim tias chromosomal hloov pauv yog ib qho xwm txheej tseem ceeb hauv carcinogenesis.
Yuav ua li cas ntawm cov micro nucleus yog dab tsi?
Lub micronucleus yog chaw cia rau cov kab mob genetic khoom ntawm cov kab mob. Nws ua rau cov macronucleus thiab yog lub luag hauj lwm rau cov genetic reorganization uas tshwm sim thaum lub sij hawm conjugation (cross-fertilization).
Qhov loj ntawm micronucleus yog dab tsi?
Micronuclei tsim tuaj yeem muaj ntau qhov ntau thiab tsawg tab sis feem ntau txawv ntawm 1/10 mus rau 1/100th qhov loj ntawm thawj nucleus.