Hauv cytosol, glycogen tawg lossis glycogenolysis yog ua los ntawm ob lub enzymes, glycogen phosphorylase uas tso cov piam thaj 1-phosphate los ntawm cov kab sib txuas ntawm glycogen, thiab glycogen debranching enzyme uas untangles ceg cov ntsiab lus. Hauv lysosomes, glycogen degradation yog catalyzed los ntawm α- glucosidase
glycogen degraded li cas?
glycogen degradation muaj peb kauj ruam: (1) tso tawm cov piam thaj 1-phosphate los ntawm glycogen, (2) kev hloov kho ntawm glycogen substrate kom tso cai ntxiv degradation, thiab (3) Kev hloov pauv ntawm qabzib 1-phosphate rau hauv qabzib 6-phosphate rau cov metabolism ntxiv.
Yuav ua li cas enzymes zom glycogen?
Glycogen phosphorylase, qhov tseem ceeb enzyme hauv glycogen tawg, cleaves nws cov substrate los ntawm kev ntxiv ntawm orthophosphate (P i) kom tawm tau cov piam thaj 1-phosphate. Lub cleavage ntawm daim ntawv cog lus los ntawm kev sib ntxiv ntawm orthophosphate yog hu ua phosphorolysis.
Dab tsi yog qhov tseem ceeb enzyme ntawm glycogen degradation Glycogenolysis)?
Glycogenolysis yog txoj hauv kev biochemical uas glycogen tawg mus rau hauv qabzib-1-phosphate thiab glycogen. Cov tshuaj tiv thaiv tshwm sim hauv hepatocytes thiab myocytes. Cov txheej txheem yog raws li kev tswj hwm ntawm ob lub enzymes tseem ceeb: phosphorylase kinase thiab glycogen phosphorylase
Qhov enzyme twg yog lub luag haujlwm rau degrading glycogen rau qabzib?
Glycogenolysis yog kev tawg ntawm glycogen (n) rau qabzib-1-phosphate thiab glycogen (n-1). Glycogen ceg yog catabolized los ntawm kev tshem tawm cov piam thaj monomers ntawm phosphorolysis, los ntawm enzyme glycogen phosphorylase.
