Kev hloov pauv tsis zoo tshwm sim thaum muaj qhov yuam kev hauv DNA code thiab ib qho ntawm DNA puag khub hloov pauv, piv txwv li, A yog pauv rau C. Qhov kev hloov pauv no. txhais tau hais tias DNA tam sim no encodes rau ib tug sib txawv amino acid, hu ua ib tug hloov.
Ntau npaum li cas cov kev hloov pauv tsis zoo tshwm sim?
Cov chav kawm ntau tshaj plaws ntawm kev hloov pauv protein ntau yog kev hloov pauv tsis zoo, qhov twg ib qho codon hloov pauv mus rau encode ib qho amino acid sib txawv. Ntawm nruab nrab, 2% ntawm cov tib neeg muaj kev hloov pauv tsis zoo nyob rau hauv ib qho gene muab(2).
Yuav ua li cas hauv kev hloov pauv tsis zoo?
Ib qho kev hloov pauv tsis zoo yog thaum qhov hloov pauv ntawm ib khub hauv paus ua rau hloov pauv ntawm cov amino acid sib txawv hauv cov protein uas tshwm sim. Qhov kev hloov pauv amino acid no yuav tsis muaj txiaj ntsig, lossis nws yuav ua rau cov protein tsis ua haujlwm.
Kev hloov pauv tshwm sim li cas?
Kev hloov pauv tshwm sim tsis tu ncua ntawm qhov tsawg zaus vim muaj tshuaj lom neeg tsis ruaj khov ntawm purine thiab pyrimidine hauv paus thiab ua yuam kev thaum lub sijhawm DNA rov ua dua. Lub ntuj raug tus kab mob rau tej yam ib puag ncig, xws li lub teeb ultraviolet thiab tshuaj carcinogens (piv txwv li, aflatoxin B1), kuj tuaj yeem ua rau kev hloov pauv.
Kev hloov pauv tshwm sim nyob qhov twg Yuav hloov pauv li cas?
Kev hloov pauv tuaj yeem tshwm sim los ntawm DNA luam yuam kev ua thaum lub sijhawm faib cell, raug rau ionizing hluav taws xob, raug rau cov tshuaj hu ua mutagens, lossis kis los ntawm cov kab mob Kab mob hloov pauv tshwm sim hauv cov qe thiab phev thiab tuaj yeem kis mus rau cov xeeb ntxwv, thaum somatic kev hloov pauv tshwm sim hauv lub cev hlwb thiab tsis dhau mus.
