Sodium-dependent glucose cotransporters yog tsev neeg ntawm cov piam thaj thauj khoom pom nyob rau hauv cov hnyuv mucosa ntawm cov hnyuv me thiab cov tubule ze ze ntawm nephron. Lawv pab txhawb rau lub raum qabzib reabsorption. Hauv ob lub raum, 100% ntawm cov kua nplaum lim hauv lub glomerulus yuav tsum tau reabsorbed raws nephron.
Na +/ glucose cotransporter ua haujlwm li cas?
Sodium-glucose cotransporter (SGLT) kev ua haujlwm mediates apical sodium thiab qabzib thauj hla cov cell membranesCotransport yog tsav los ntawm kev nquag sodium extrusion los ntawm basolateral sodium / potassium-ATPase, yog li yooj yim. Glucose uptake tawm tsam ib qho intracellular up-hill gradient.
Kev thauj mus los ntawm sodium-dependent glucose yog dab tsi?
Sodium-dependent glucose cotransporters (los yog sodium-glucose linked transporter, SGLT) yog tsev neeg ntawm cov piam thaj thauj khoom pom nyob rau hauv cov hnyuv mucosa (enterocytes) ntawm txoj hnyuv me (SGLT1) thiab cov tubule ze ze ntawm nephron (SGLT2 hauv PCT thiab SGLT1 hauv PST). Lawv pab txhawb rau lub raum qabzib reabsorption.
Puas qabzib thauj nrog sodium?
Ob lub sodium ions raug thauj los ntawm SGLT1 rau txhua lub qabzib molecule, thiab cov cotransporter no tau tso cai thauj cov piam thaj rau hauv cov hlwb tiv thaiv nws cov concentration gradient 4.
Hom kev thauj khoom twg yog sodium-glucose cotransporter?
SGLT1 siv lub zog hauv kev txav chaw qis qis ntawm Na+ txhawm rau thauj cov piam thaj hla lub apical membrane tiv thaiv cov piam thaj nce siab kom cov piam thaj tuaj yeem thauj mus rau hauv cov hlab ntsha.
Glucose Transporters (GLUTs and SGLTs) - Biochemistry Lesson
