Kev khi ntawm acetylcholine rau nws cov receptor activates cov leegthiab ua rau cov leeg nqaij. Hauv myasthenia gravis, cov tshuaj tiv thaiv kab mob (cov tshuaj tiv thaiv kab mob uas tsim los ntawm lub cev tiv thaiv kab mob) thaiv, hloov, lossis rhuav tshem cov receptors rau acetylcholine ntawm cov hlab ntsha neuromuscular, uas tiv thaiv cov leeg ntawm kev cog lus.
Qhov tshwm sim ntawm acetylcholine receptor puas tsuaj hauv myasthenia gravis yog dab tsi?
Myasthenia gravis (MG) yog ib qho kab mob autoimmune uas autoantibodies tawm tsam acetylcholine receptor (AChR) ntawm neuromuscular junction (NMJ) ua rau cuam tshuam cov kab mob neuromuscular, ua rau hloov pauv. Tsis muaj zog ntawm cov leeg pob txha, ua rau diplopia, ptosis, dysarthria, dysphagia, thiab limb…
Cov receptors twg cuam tshuam hauv myasthenia gravis?
Myasthenia gravis (MG) yog tus kab mob ntawm postsynaptic neuromuscular junction (NMJ) qhov twg nicotinic acetylcholine (ACh) receptors (AChRs) yog tsom los ntawm autoantibodies.
Puas myasthenia gravis tshwm sim vim lub cev tsis ua acetylcholine?
Myasthenia gravis tshwm sim thaum lub cev tsis muaj zog ua rau antibodies uas rhuav tshem ACh receptor (AChR), qhov chaw docking rau cov paj hlwb acetylcholine (ACh). Qee qhov kev kho mob thaiv acetylcholinesterase (AChE), ib qho enzyme uas ua rau ACh, thaum lwm tus tsom rau lub cev tiv thaiv kab mob.
Acetylcholine antibodies ua dab tsi?
AChR cov tshuaj tiv thaiv cuam tshuam kev sib txuas lus ntawm cov hlab ntsha thiab cov leeg pob txha, inhibit cov leeg nqaij, thiab ua rau cov nqaij leeg nrawm los ntawm kev tiv thaiv kev ua kom cov acetylcholine receptors.
