Tshuaj muab los ntawm i.v. txoj kev muaj absolute (100%) bioavailability vim lawv zam cov kab mob siab thawj zaug.
Pob cov tshuaj tso rau hauv lub siab?
Thaum kawg lub vasculature redistributes cov tshuaj rov qab mus rau lub siab los ntawm lub hepatic artery. Thawj zaug dhau metabolism txiav txim siab qhov feem ntawm qhov ncauj koob tshuaj yuav ncav cuag txoj kev ncig - cov feem bioavailable. Cov tshuaj hauv cov hlab ntsha tsis muaj qhov cuam tshuam thawj zaugthiab yog, los ntawm txhais, 100% bioavailable.
Txhua yam tshuaj hla lub siab?
Cov tshuaj feem ntau yuav tsum dhau los ntawm lub siab, uas yog qhov chaw tseem ceeb rau cov tshuaj metabolism. Ib zaug nyob rau hauv daim siab, enzymes hloov prodrugs mus rau active metabolites los yog hloov active tshuaj mus rau inactive cov ntaub ntawv. Lub siab lub hauv paus txheej txheem rau metabolizing tshuaj yog los ntawm ib pab pawg neeg ntawm cytochrome P-450 enzymes.
Puas yog cov tshuaj hauv cov hlab ntsha puas metabolised?
Qhov ib puag ncig acidic thiab digestive enzymes hauv plab kuj tseem tuaj yeem ua rau qee yam tshuaj degrade, ua rau kev nqus tsis zoo. Nyob rau hauv sib piv, tshuaj txhaj tshuaj intravenously tsis undergo absorptionthiab yog li ntawd tag nrho cov koob mus txog rau lub dav dav ncig.
Yuav ua li cas cov tshuaj tso rau hauv cov hlab ntsha tau metabolized?
Tom qab siv tshuaj, nws nkag mus rau hauv cov hlab ntsha. Lub circulatory system ces faib cov tshuaj thoob plaws hauv lub cev. Tom qab ntawd nws yog metabolized los ntawm lub cev. Cov tshuaj thiab nws cov metabolites tom qab ntawd raug tso tawm.
