Glucose tsis tuaj yeem tsim los ntawm fatty acids , vim lawv tau hloov los ntawm β-oxidation rau hauv acetyl coenzyme A (CoA), uas tom qab nkag mus rau lub voj voog citric acid thiab oxidized rau CO2.
Yuav ua li cas cov precursors tuaj yeem siv los ua cov piam thaj hauv gluconeogenesis?
Txoj kev gluconeogenic hloov pauv pyruvate mus rau hauv qabzib. Noncarbohydrate precursors ntawm qabzib yog thawj zaug hloov mus rau hauv pyruvate los yog nkag mus rau hauv txoj kev tom qab intermediates xws li oxaloacetate thiab dihydroxyacetone phosphate (Daim duab 16.24). Qhov tseem ceeb uas tsis yog carbohydrate precursors yog lactate, amino acids, thiab glycerol.
Dab tsi ua rau cov piam thaj synthesis?
Tshwj xeeb, glucagon txhawb lub siab hloov pauv ntawm glycogen rau qabzib (glycogenolysis), txhawb nqa de novo qabzib synthesis (gluconeogenesis), thiab inhibits piam thaj (glycolysis) thiab tsim glycogen (glycogenesis)) (Fig.
Dab tsi ntawm cov hauv qab no yog qhov ua ntej ntawm glycogen?
Dab tsi ntawm cov hauv qab no yog qhov ua ntej ntawm glycogen? Kev piav qhia: Glucose 1-phosphate thiab uridine triphosphate ua haujlwm ua ke los qhib UDP-glucose uas ua haujlwm ua ntej ntawm glycogen. Kev piav qhia: Glycogen synthesis yog nqa tawm nrog kev pab los ntawm primer los ntawm nws qhov kev txiav txim priming.
Dab tsi xav tau rau gluconeogenesis hauv tib neeg muab piv txwv ntawm gluconeogenic precursors?
Nyob rau hauv tib neeg lub ntsiab gluconeogenic precursors yog lactate, glycerol (uas yog ib feem ntawm triglyceride molecule), alanine thiab glutamine… Lwm yam glucogenic amino acids thiab tag nrho cov citric acid cycle intermediates (los ntawm kev hloov pauv mus rau oxaloacetate) tuaj yeem ua haujlwm ua cov substrates rau gluconeogenesis.
