Cimetidine (lub npe lag luam Tagamet) yog ib qho antagonist ntawm histamine H2-receptor uas inhibits zus tau tej cov gastric acid. … Peb cov txiaj ntsig tau pom tias cimetidine tuaj yeem cuam tshuam ALP los ntawm kev txwv tsis pub muaj kev sib twThaum tsis muaj inhibitor V (max) thiab K (m) ntawm cov enzyme tau pom tias yog 13.7 mmol / mg prot.
YPuas yog cimetidine yog ib qho kev sib tw inhibitor?
Cimetidine (Tagamet) yog thawj tiam ntawm lub zog, hydrophilic heev, kev sib tw inhibitors ntawm H 2 -receptor–mediated histamine reactions, uas tom qab ua raws li ranitidine thiab famotidine.
Yuav ua li cas inhibitor yog cimetidine tsis sib tw?
Cytochrome P450 inhibition
Cimetidine yog ib qho muaj zog inhibitor ntawm qee yam cytochrome P450 (CYP) enzymes, suav nrog CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, thiab CYP3A4. Cov tshuaj zoo li feem ntau inhibit CYP1A2, CYP2D6, thiab CYP3A4, uas nws tau piav qhia tias yog nruab nrab inhibitor
YPuas yog cimetidine yog CYP inhibitor?
Cimetidine yog tus inhibitor ntawm hepatic cytochrome P450 (CYP) hauv vivo thiab hauv vitro hauv ob nas thiab tib neeg. Txawm li cas los xij, cov ntsiab lus ntawm cimetidine yuav tsum ua rau inhibit cov tshuaj metabolism hauv hepatic microsomes hauv vitro yog 100-1000-fold siab dua li cov uas cuam tshuam nrog cov qib zoo sib xws ntawm inhibition hauv vivo.
Yuav ua li cas yog lub tswv yim ntawm kev ua ntawm cimetidine?
Cimetidine khi rau H2-receptor nyob rau ntawm daim nyias nyias ntawm lub plab parietal cell, thaiv cov teebmeem histamine. Qhov kev sib tw inhibition no ua rau txo qis gastric acid secretion thiab txo qis hauv plab ntim thiab acidity.
