Txawm hais tias pancreatic amylase thiab lipase tau zais ua cov enzymes nquag, txhua tus pancreatic digestive proteases thiab ob peb lwm cov hydrolases yog zymogens. Hauv cov hnyuv me, pancreatic zymogen activation pib nrog kev hloov pauv ntawm trypsinogen rau trypsin los ntawm txoj hnyuv txhuam-border protease enterokinase
Yuav ua li cas pancreatic enzymes qhib?
Cov proenzymes mus rau txhuam ciam teb ntawm duodenum, qhov twg trypsinogen, proenzyme rau trypsin, yog qhib qhib ntawm hydrolysis ntawm N-terminal hexapeptide fragment los ntawm txhuam ciam teb enzyme enterokinase Trypsin tom qab ntawd pab txhawb kev hloov pauv ntawm lwm cov proenzymes rau hauv lawv cov ntaub ntawv nquag.
Kev ua kom pancreatic Zymogens tshwm sim nyob qhov twg?
Nyob rau hauv cov xwm txheej physiologic, zymogens hloov mus rau cov enzymes nquag tom qab lawv ncav cuag cov hnyuv. Thaum lub sijhawm pib ntawm tus mob pancreatitis, cov zymogens tau qhib nyob rau hauv lub pancreatic acinar cell Ntau lub tswv yim tiv thaiv acinar cell los ntawm activated proteases.
Dab tsi ua rau pancreatic zymogen tso tawm?
Acinar cells secrete zymogen los ntawm exocytosis ntawm zymogen granules rau hauv acinar lumen. Lawv ua qhov no hauv kev teb rau cholinergic vagal paj hlwb stimulation, los yog rau cov tshuaj hormones circulating peptide uas cov hlwb muaj receptors. Cholecystokinin (CCK) thiab foob pobyog ob lub peptides uas txhawb nqa pancreatic secretion.
pancreatic enzyme trypsinogen ua haujlwm li cas?
Trypsinogen yog qhib los ntawm enterokinase, uas cleaves ib amino-terminal activation peptide (TAP) Active trypsin ces cleaves thiab activates tag nrho lwm yam pancreatic proteases, phospholipase, thiab colipase. Nws yog qhov tsim nyog rau kev ua haujlwm ntawm lub cev ntawm pancreatic triglyceride lipase.
