Kev hloov pauv hauv NTRK1 noob ua rau congenital insensitivity rau qhov mob nrog anhidrosis (CIPA), ib qho mob tshwm sim los ntawm qhov tsis muaj peev xwm hnov mob thiab txo qis lossis tsis tawm hws (anhidrosis).
NTRK1 yog dab tsi?
NTRK1 noob encodes the neurotrophic tyrosine kinase-1 receptor thiab belongs rau tsev neeg ntawm cov paj hlwb loj hlob receptors uas ligands suav nrog neurotrophins. Neurotrophins thiab lawv cov receptors ua lub luag haujlwm tseem ceeb hauv kev tswj kev txhim kho ntawm ob qho tib si hauv nruab nrab thiab lub paj hlwb peripheral.
NTRK1 noob nyob qhov twg?
Tus TRKA (NTRK1) noob nyob on chromosome 1 (1q21-q22), muaj 17 exons thiab spans tsawg kawg yog 23 kb. TRKA encodes tus receptor tyrosine kinase (RTK) rau paj hlwb loj hlob (NGF) thiab yog cov noob lub luag haujlwm rau CIPA.
NTRK1 sawv cev rau dab tsi?
NTRK1 ( Neurotrophic Receptor Tyrosine Kinase 1) yog Protein Coding gene. Cov kab mob cuam tshuam nrog NTRK1 suav nrog Insensitivity To Pain, Congenital, With Anhidrosis thiab Thyroid Carcinoma, Familial Medullary. Ntawm nws txoj kev muaj feem cuam tshuam yog MAPK Kev Tshaj Tawm: Mitogens thiab GPCR Pathway.
Met noob yog dab tsi?
Ib tug noob uas ua rau cov protein uas koom nrog hauv kev xa cov cim hauv hlwb thiab hauv kev loj hlob ntawm tes thiab ciaj sia. Mutated (hloov) cov ntaub ntawv ntawm MET gene tuaj yeem ua rau cov hlwb txawv txav kom loj hlob thiab sib kis hauv lub cev.
