Nws yog dav xav tias C-NHEJ kuj yog qhov ua yuam kev, vim cov txheej txheem kho kho cuam tshuam nrog kev ua tiav ntawm DNA xaus ntawm qhov chaw tawg, uas tuaj yeem ua rau tshem tawm nucleotideYog li, kev koom nrog cov DNA no xaus ntawm C-NHEJ hauv thaj av uas tau sau tseg tuaj yeem yog mutagenic thiab/lossis tuag rau cov hlwb.
Vim li cas NHEJ suav hais tias yog qhov ua yuam kev yuam kev?
Ib qho tseem ceeb, NHEJ yog txoj hauv kev kho qhov yuam kev. Vim cov txheej txheem tsis siv tus qauv ua ke, kev sib xyaw ntawm cov DNA duplexes uas tsis muaj tseeb yuav ua rau muaj kev tshem tawm lossis tso cov khub hauv paus.
Puas yog homologous recombination yuam kev prone?
Homologous recombination (HR) yog cov txheej txheem evolutionarily kev txuag uas ua lub luag haujlwm tseem ceeb hauv kev sib npaug ntawm cov caj ces ruaj khov thiab ntau haiv neeg. HR feem ntau suav hais tias tsis muaj qhov yuam kev, tab sis ntau qhov kev tshawb fawb tau pom tias HR tuaj yeem ua yuam kev.
NHEJ kho dab tsi?
Non-homologous end joining (NHEJ) is a pathway that repairs two-strand breaks in DNA… Thaum lub overhangs tau zoo kawg nkaus, NHEJ feem ntau kho qhov tawg kom raug. Kev kho tsis ncaj ncees ua rau poob ntawm nucleotides kuj tuaj yeem tshwm sim, tab sis muaj ntau dua thaum cov overhangs tsis sib xws.
Yuav ua li cas kho qhov yuam kev yog dab tsi?
RecA protein, txhawb nqa los ntawm ib leeg-stranded DNA, koom nrog hauv kev tsis ua haujlwm ntawm kev tawm tsam (LexA) ntawm SOS cov noob caj noob ces thiaj li ua rau cov lus teb. Nws yog qhov kev kho tsis raug uas ua rau muaj txiaj ntsig zoo rau DNA hloov pauv tau pom nyob rau hauv ntau hom.
