Proneural genes encode transcription yam ntawm cov chav kawm helix-loop-helix uas yog lub luag haujlwm rau kev tsim cov hlwb neuroectodermal progenitor. Proneural genes muaj ntau yam haujlwm hauv kev loj hlob neural.
Cov hlwb proneural yog dab tsi?
Proneural genes yog thawj zaug qhia nyob rau hauv neuroepithelial cells uas twb tau teev tseg rau txoj hmoo neural thiab rov ua nws tus kheej. Proneural kev ua ub no tshwm sim nyob rau hauv tiam thiab delamination ntawm progenitors uas txwv rau lub neuronal txoj hmoo thiab muaj ib tug txwv mitotic peev xwm.
Cov noob caj noob ces yog dab tsi?
Abstract. Cov noob neurogenic ntawm Delta-Notch signaling pathway mediate lateral inhibition-a mechanism uas tswj kev cog lus ntawm tes hauv ntau cov ntaub so ntswg thiab ua haujlwm hauv kev tsim cov paj hlwb rau ib leeg tawm hlwb rau txoj hmoo neural.
Proneural glioblastoma yog dab tsi?
Proneural glioblastoma yog ib txwm muaj nyob rau hauv cov tub ntxhais hluas, sib raug rau qhov thib ob glioblastoma subtype, muaj neuronal sib txawv, thiab cuam tshuam nrog cov txiaj ntsig zoo dua. Yog tus cwj pwm los ntawm IDH / TP53 kev hloov pauv / qhov zoo rau glioma-CpG kob methylator phenotype (G-CIMP) thiab ib txwm EGFR / PTEN / Notch signaling.
Dab tsi yog cov subtypes ntawm glioblastoma?
Plaub GBM molecular subtypes yog proneural, neural, classical, thiab mesenchymal.
