Thaum kub poob qis, oxy-Hb nkhaus yuav dhau los ua ntaus. Qhov nce siab ntawm qhov nkhaus qhia tias muaj kev sib raug zoo ntawm Hb rau O2.
Qhov kub li cas cuam tshuam rau oxyhemoglobin nkhaus?
Yog li ntawd ntawm cov ntshav plasma kub siab dua, hemoglobin yuav tsis tshua khi rau oxygen thiab ntau dua yuav tshem tawm mus rau hauv cov hlwb ntawm cov ntaub so ntswg. Yog li ntawd, raws li kub nce, qhov no hloov tag nrho cov pa oxygen-hemoglobin dissociation nkhaus mus rau sab xis.
Yuav ua li cas cuam tshuam rau cov pa oxygen dissociation nkhaus yog qhov kub thiab txias?
Qhov cuam tshuam ntawm qhov kub ntawm qhov nkhaus yog qhov ncaj ncaj. Oxygen unloading yog nyiam ntawm qhov kub siab dua uas yuav ua rau muaj kev hloov mus rau txoj cai. Ntawm qhov tod tes, qhov ntsuas kub qis dua yuav ua rau sab laug hloov pauvhauv qhov nkhaus dissociation.
Dab tsi ua rau oxyhemoglobin nkhaus mus rau sab laug?
Cov yam ntxwv ntawm lub cev uas ua rau sab laug hloov ntawm O2 nkhaus yog siab dua pH (piv txwv li, pH 7.5) thiab txias dua (piv txwv li, 35 ° C) hemoglobin variants kuj tuaj yeem pom ntau dua O2 affinity. … Physiological yam uas txo O2 affinity yog pH tsawg, siab CO2 concentrations, siab kub, thiab siab 2, 3-DPG.
Dab tsi ua rau txoj cai hloov pauv hauv oxyhemoglobin dissociation nkhaus?
Cov yam ntxwv uas ua rau hloov pauv ntawm cov pa oxygen-dissociation nkhaus mus rau sab xis suav nrog nce siab ntawm pCO2, acidosis, nce qhov kub thiab txias siab ntawm 2, 3 diphosphoglycerate (2, 3 DPG)Cov xwm txheej no, qhov tshwm sim, ua rau Hb tso pa oxygen yooj yim dua.