Tsis muaj kev sib tw inhibition tshwm sim thaum tus inhibitor khi rau cov enzyme ntawm qhov chaw uas tsis yog qhov chaw nquag … Nyob rau tom kawg, tus inhibitor tsis tiv thaiv kev khi ntawm lub substrate rau lub enzyme. tab sis txaus hloov cov duab ntawm qhov chaw uas catalytic kev ua si tshwm sim los tiv thaiv nws.
Tus neeg tsis sib tw ua haujlwm li cas?
Nyob rau hauv noncompetitive inhibition, tus inhibitor tsis thaiv lub substrate los ntawm khi rau lub active site. Hloov chaw, nws txuas ntawm lwm qhov chaw thiab thaiv cov enzyme los ntawm kev ua nws txoj haujlwmQhov kev txwv no tau hais tias "tsis sib tw" vim tias cov inhibitor thiab substrate tuaj yeem ua ob qho tib si tib lub sijhawm.
Yuav ua li cas thiaj tsis sib tw inhibitor ua haujlwm ntawm ib qho enzyme?
A noncompetitive inhibitor ua los ntawm kev txo tus lej hloov pauv ntau dua li ntawm kev txo qis ntawm cov enzyme molecules uas raug khi rau substrateTsis sib tw inhibition, sib piv nrog kev sib tw inhibition, tsis tuaj yeem kov yeej. los ntawm kev ua kom cov substrate concentration.
Dab tsi yog cov piv txwv tsis sib tw inhibitors?
Tus inhibitory teebmeem ntawm cov hlau hnyav, thiab ntawm cyanide ntawm cytochrome oxidase thiab ntawm arsenate ntawm glyceraldehyde phosphate dehydrogenase, yog cov piv txwv ntawm kev txwv tsis pub sib tw. Hom inhibitor no ua los ntawm kev sib txuas nrog cov enzyme hauv txoj hauv kev uas vim qee qhov chaw ua haujlwm tau ua haujlwm tsis ua haujlwm.
Vim li cas thiaj tsis sib tw inhibitors txo Vmax?
Tsis-Competitive Inhibition
Qhov no yog vim qhov ua rau substrate ua kom cov feem pua ntawm cov enzyme nquag. Nrog tsis muaj kev sib tw inhibition, nce tus nqi ntawm cov substrate tsis muaj kev cuam tshuam rau feem pua ntawm cov enzyme uas ua haujlwm. … Txo cov enzyme tam sim no txo Vmax
