BDNF yog ib tus tswv cuab ntawm tsev neeg neurotrophin ntawm kev loj hlob nrog rau cov paj hlwb (NGF); neurotrophins-3 (NT-3), NT4/5 thiab NT-6. BDNF yog synthesized nyob rau hauv endoplasmic reticulum (ER) raws li 32–35 kDa precursor protein (pro BDNF) uas txav los ntawm Golgi apparatus thiab trans-Golgi network (TGN).
Koj tsim BDNF li cas?
Yuav ua li cas nce BDNF: 10 Txoj hauv kev los nce koj qib BDNF
- Control Stress and Inflamation Levels. …
- Kev ua haujlwm tsis tu ncua. …
- Ua ntej koj qhov kev sib raug zoo. …
- ua pa tsw qab thiab liab qab nyob rau hauv lub hnub. …
- Caw kas fes thiab noj kas fes Berry ntxiv. …
- Siv cov khoom noj muaj protein ntau. …
- txwv tsis pub Carbohydrate kom tsawg (Qee zaum) …
- Nyob nrawm nrawm.
BDNF nyob qhov twg?
Nyob hauv lub hlwb nws ua haujlwm hauv the hippocampus, cortex, thiab basal forebrain -cov cheeb tsam tseem ceeb rau kev kawm, nco, thiab kev xav siab dua. BDNF kuj tau hais tawm hauv retina, ob lub raum, prostate, lub cev muaj zog neurons, thiab cov leeg pob txha, thiab tseem muaj nyob hauv cov qaub ncaug. BDNF nws tus kheej yog qhov tseem ceeb rau kev nco mus ntev.
Dab tsi zais BDNF?
BDNF synthesis, ua, txheeb, thauj thiab tso tawm hauv cov neurons. BDNF yog synthesized nyob rau hauv lub endoplasmic reticulum (ER) raws li ib tug 32 kDa precursor protein (proBDNF) uas txav txawm lub Golgi apparatus mus rau lub trans Golgi network (TGN), los ntawm qhov uas nws hla mus rau hauv lub constitutive thiab tswj secretory pathways.
Dab tsi txhawb nqa BDNF tso tawm?
Calcium transients thiab BDNF secretion nyob rau hauv teb rau hluav taws xob stimulation. Hauv cov neurons, calcium influx ntawm pre- lossis postsynaptic NMDA receptors pab txhawb rau hluav taws xob induced BDNF tso tawm ntawm qhov chaw tso tawm (Hartmann li al. 2001; Matsuda li al. 2009; Park 2018).
