Nucleosides yog ib qho tseem ceeb ntawm cov roj ntsha molecules uas ua haujlwm raws li kev taw qhia cov molecules thiab ua cov precursors rau nucleotides xav tau rau DNA thiab RNA synthesis. Synthetic nucleoside analogues yog siv nyob rau hauv kev kho mob rau kho ntau yam mob qog noj ntshav thiab kis kab mob.
Vim li cas thiaj siv nucleosides?
Cov nucleoside analogues yog ib chav tseem ceeb ntawm cov tshuaj tiv thaiv kab mob tam sim no feem ntau siv rau hauv kev kho mob human immunodeficiency virus (HIV) kab mob, kab mob siab B (HBV), kab mob siab C. (HCV), cytomegalovirus (CMV), herpes simplex virus (HSV) thiab varicella-zoster (VZV) kab mob.
Nucleosides muab piv txwv li cas?
Piv txwv ntawm nucleosides suav nrog cytidine, uridine, guanosine, inosine thymidine, thiab adenosine. Ib daim ntawv cog lus beta-glycosidic khi 3 'txoj hauj lwm ntawm pentose qab zib rau cov nitrogenous puag. Nucleosides yog siv los ua tshuaj tua kab mob thiab tshuaj tua kab mob.
Nucleotides siv nyob qhov twg?
Ntxiv rau kev tsim cov blocks rau kev tsim kho ntawm nucleic acid polymers, cov lus nucleotides ua lub luag haujlwm hauv cellular zog cia thiab muab, xov tooj ntawm tes taw qhia, raws li cov pab pawg phosphate siv. los hloov cov kev ua ntawm cov proteins thiab lwm yam signaling molecules, thiab raws li enzymatic cofactors, feem ntau…
Nucleoside yog dab tsi muab ob qho piv txwv?
Nyob rau hauv nucleoside, cov pa roj carbon monoxide txuas los ntawm glycosidic daim ntawv cog lus rau N9 ntawm purine lossis N1 ntawm pyrimidine. Piv txwv ntawm nucleosides suav nrog cytidine, [pawg cawv (-CH2-OH) los tsim nucleotides. Nucleotides yog lub tsev molecular blocks ntawm DNA thiab RNA.
